Ribonucleotide reductase M2 (RRM2) is a small subunit in ribonucleotide reductases, which participate in nucleotide metabolism and catalyze Dustpan the conversion of nucleotides to deoxynucleotides, maintaining the dNTP pools for DNA biosynthesis, repair, and replication.RRM2 performs a critical role in the malignant biological behaviors of cancers
Optimal designs for population pharmacokinetic studies of oral artesunate in patients with uncomplicated falciparum malaria
Abstract Background Currently, population pharmacokinetic (PK) studies of anti-malarial drugs are designed primarily by the logistical and ethical constraints of taking blood samples from patients, and the statistical models that are fitted to the data are not formally considered.This could lead to imprecise estimates of the target PK parameters, a
Engineering-psychological problems of unmanned aerial vehicles interface design
Background.Unmanned aerial vehicles (UAVs) are nowadays widely used in various domains.Their use is connected with a broad range of psychological problems, in particular, within engineering psychology.Objective.In this paper, typical engineering-psychological problems of interface design for UAVs are considered.Design.Literature survey on topic rel
Administrative Detention: Compliance of the Code of Ukraine on Administrative Offenses with Social Needs and the Current State of Keeping Human Rights and Freedoms
The author has studied administrative detention as a measure to ensure proceedings L-GLUTATHIONE in cases on administrative offenses, its use in documenting administrative offenses and interdependent measures, as well as the use of data obtained as evidence in proceedings in cases on administrative offenses.One of the effective means of ensuring pr
Incidence and factors associated with agitation in patients on mechanical ventilators in Amhara Region, North-West Ethiopia: a multi-center study
Abstract Agitation is a common psychomotor disorder among critically CEYLON CINNAMON ill patients on mechanical ventilators, posing significant risks to patients and adding strain to clinical services.Despite its importance, there is a lack of data on the incidence and contributing factors of agitation in the study area and across Ethiopia.This stu